Paracetamol Paracetamol is an organic compound, chemical formula C8H9NO2, which is the metabolic product of Phenacetin in vivo. It reduces the synthesis and release of Prostaglandin PGE1, Bradykinin and histamine by inhibiting Prostaglandin synthetase in the hypothalamic Thermoregulation center. PGE1 mainly acts on the nerve center. Its decrease will lead to the decrease of the central temperature setting point, and the body surface temperature sensor will feel relatively hot, which will then lead to the expansion of peripheral blood vessels and sweating through Neuromodulation to achieve the antipyretic effect. Its inhibition of Prostaglandin synthesis in the central nervous system is similar to aspirin, but its anti-inflammatory effect is weak. No effect on platelets and coagulation mechanisms
